The situation is particularly acute in Bolivia, where Foreign Minister Karen Longaric became the ninth high ranking official to test positive for Covid-19 on Monday.
She joins a host of her colleagues -- including Ministers for Health, Economy, Justice, and the Interior -- as well as Bolivian Interim President Jeanine Añez, who tested positive last week and is currently under quarantine.
Añez is the third Latin American head of state to contract the virus, following Brazil's President Jair Bolsonaro and Honduran President Juan Orlando Hernandez.
Bolsonaro, who repeatedly downplayed the coronavirus crisis, remains in semi-isolation.
The pandemic's new epicenter
Latin America became the epicenter of the global pandemic in late May. Cases in the region surpassed the 3 million mark on Monday, and contribute significantly to recent record rises in global case numbers.
Brazil has the second highest number of coronavirus cases globally, after the US, with more than 1.8 million people in the country testing positive.
In impoverished Venezuela, where concerns have been raised over the country's crippled healthcare system, the virus also appears to be spreading.
Diosdado Cabello, the president of Venezuela's National Constituent Assembly, announced he had tested positive on 9 June. Cabello is considered Venezuela's second most powerful official after embattled president Nicolas Maduro.
The country's oil minister Tareck El Aissami has also tested positive.
On Tuesday, a CNN analysis of Johns Hopkins University data found that Latin America and the Caribbean had now suffered more coronavirus deaths than the US and Canada -- though the latter have still suffered more reported deaths per capita.
As a whole, the Americas reported 60% of all new Covid-19 cases in the world during the past week, and 64% of all new deaths, according to Dr. Carissa Etienne, director of the Pan American Health Organization.
During a press briefing Tuesday, Etienne said the region has reached 6.8 million cases and 288,000 deaths.
"This equates to roughly half of all cases and deaths reported around the world," she said.